重磅免疫檢查點(diǎn)CTLA-4 (E2V1Z) Rabbit mAb上市 | CST 12月新品上市
Dec. 2021
熱門新產(chǎn)品
CTLA-4 (E2V1Z) Rabbit mAb #53560
| 貨號(hào) | 規(guī)格 | 2021 年目錄價(jià) |
|
53560T |
20 μl |
￥1,400.00 |
| 53560S | 100 μl | ￥3,850.00 |
CTLA-4 (E2V1Z) Rabbit mAb (BSA and Azide Free) #26893
| 貨號(hào) | 規(guī)格 | 2021 年目錄價(jià) |
|
26893SF |
100 μg |
￥7,400.00 |
細(xì)胞毒性 T 淋巴細(xì)胞蛋白 4 (CTLA-4, CD152) 是 Ig 超家族的一員，能夠負(fù)向調(diào)控 T 細(xì)胞的早期激活 (1-4)。CTLA-4 蛋白主要在 T 細(xì)胞中表達(dá)，包括 CD8+ 細(xì)胞毒性 T 細(xì)胞、CD4+ 輔助 T 細(xì)胞和 CD4+/FoxP3+ 調(diào)節(jié)性 T 細(xì)胞（1,2）。CTLA-4 蛋白與 CD28 在細(xì)胞表面爭(zhēng)相結(jié)合 B7.1 (CD80) 和 B7.2 (CD86)，導(dǎo)致 T 細(xì)胞活性下調(diào) (5)。CTLA-4 下游 SHP-2 和 PP2A 的激活會(huì)減弱 TCR 信號(hào)轉(zhuǎn)導(dǎo) (6)。研究表明，CTLA4 敲除小鼠患有引起過早死亡的淋巴組織增殖性疾病，表明 CTLA-4 可負(fù)向調(diào)控 T 細(xì)胞 (7)。相應(yīng) CTLA4 基因突變與多種疾病有關(guān)，包括胰島素依賴性糖尿病、格雷夫斯病、橋本甲狀腺炎、乳糜瀉、系統(tǒng)性紅斑狼瘡和 V 型自身免疫性淋巴細(xì)胞增殖性綜合征 (8,9)。其他研究表明，CTLA-4 阻滯是腫瘤免疫治療的有效策略 (10-12)。
CST CTLA-4 (E2V1Z) Rabbit mAb #53560 的重要性：CTLA-4 是免疫治療領(lǐng)域一個(gè)非常重要的轉(zhuǎn)化醫(yī)學(xué)相關(guān)靶點(diǎn)。研究人員需要觀察腫瘤組織微環(huán)境中該靶標(biāo)的表達(dá)情況，以識(shí)別腫瘤微環(huán)境當(dāng)中免疫細(xì)胞的表型和功能。CST CTLA-4 抗體（#53560）是目前市面上兩款用于 IHC-P應(yīng)用的科研抗體之一，在十多種癌癥組織樣本當(dāng)中進(jìn)行了嚴(yán)格的驗(yàn)證 （滑動(dòng)查看下方驗(yàn)證數(shù)據(jù)），適用于手動(dòng)和基于自動(dòng)染色機(jī)的免疫組化實(shí)驗(yàn)，是性價(jià)比之選。
同時(shí)，無載體配方CTLA-4 (E2V1Z) Rabbit mAb (BSA and Azide Free) #26893 也可以滿足包括質(zhì)譜流式，成像質(zhì)譜流式等各種需要特殊抗體偶聯(lián)的需求，是助力研究人員深入了解腫瘤免疫以及腫瘤微環(huán)境并開展轉(zhuǎn)化醫(yī)學(xué)研究的不二選擇。
12月新品列表
|
產(chǎn)品貨號(hào) |
產(chǎn)品名稱 |
實(shí)驗(yàn)應(yīng)用 |
反應(yīng)性 |
| ?Adhesion / ECM | |||
| 63034S |
COL3A1 (E8D7R) XP? Rabbit mAb |
WB, IHC-P |
H |
|
MUC5B (E4Y5Z) Rabbit mAb |
IHC-P, IF-IC |
H |
|
|
MUC13 (E6Z1K) Rabbit mAb |
WB, IP, IHC-P, IF-IC |
H |
|
|
PAI-1 (E3I5H) XP? Rabbit mAb |
WB, IHC-P |
H |
|
|
Periostin (E5F2S) Rabbit mAb |
WB, IP, IHC-P |
H |
|
|
Apoptosis |
|||
| 40618S | Gasdermin E Antibody | WB | M, R |
| 88169S | Mcl-1 (D2W9E) Rabbit mAb (Alexa Fluor? 594 Conjugate) | IF-IC, F | H, M, R |
| 66026S | PARP (46D11) Rabbit mAb (Alexa Fluor? 488 Conjugate) | F | H, M, R, Mk |
| 53727S | PARP (46D11) Rabbit mAb (Alexa Fluor? 594 Conjugate) | F | H, M, R, Mk |
| 34366S | PARP (46D11) Rabbit mAb (Alexa Fluor? 647 Conjugate) | F | H, M, R, Mk |
| 58274S | Phospho-RIP (Ser320) Antibody | WB | H |
|
Autophagy |
|||
|
CCPG1 (E3C5G) Rabbit mAb |
WB, IP |
H |
|
| 12074S | Phospho-SQSTM1/p62 (Ser349) (E7M1A) Rabbit mAb (Alexa Fluor? 488 Conjugate) | IF-IC, F | H, M, (R) |
|
Ca, cAMP and Lipid Signaling |
|||
|
PhosphoPlus? PLCγ2 (Tyr759) Antibody Duet |
- |
- |
|
|
Cell Cycle / Checkpoint Control |
|||
|
Phospho-Rb (Ser807) Antibody |
WB |
H |
|
|
XRCC1 (E4A3V) XP? Rabbit mAb |
WB, IP, IHC-P, IF-IC |
H, M, R |
|
|
Chromatin Regulation / Nuclear Function |
|||
| FTSJ3 (E6T9J) Rabbit mAb | WB | H, M | |
|
Tri-Methyl-Histone H3 (Lys27) (C36B11) Rabbit mAb (Alexa Fluor? 555 Conjugate) |
F |
H, M, R, Mk, (X, Z) |
|
|
Tri-Methyl-Histone H3 (Lys27) (C36B11) Rabbit mAb (Alexa Fluor? 594 Conjugate) |
F |
H, M, R, Mk, (X, Z) |
|
| 88197C | FastScan? LbCpf1 (Strain ND2006) ELISA Kit | ELISA | - |
|
MLL1 (E9W9Z) Rabbit mAb (Carboxy-terminal Antigen) |
WB, IP, ChIP |
H, Mk |
|
|
TIF1α/TRIM24 (E9T3N) Rabbit mAb |
WB, IP, IHC-P |
H, M, R, Mk |
|
|
TTF-I Antibody |
WB |
H, M, R, Mk |
|
|
Cytoskeletal Signaling |
|||
| 47610S | KIF5B (E3H4J) Rabbit mAb | WB, IF-IC | H, M, R |
| 62696S | KIF5B (E4A5A) Rabbit mAb | WB, IP, IF-IC | H |
| 47293S | SETD3 Antibody | WB, IP | H, Mk |
| 37430S | ZNF185 (E6W4I) Rabbit mAb | WB, IP, IF-IC | H |
| 86942S | ZO-1 (D6L1E) Rabbit mAb (Alexa Fluor? 488 Conjugate) | IF-IC | H, Mk |
| 98225S | ZO-1 (D6L1E) Rabbit mAb (Alexa Fluor? 647 Conjugate) | IF-IC | H, Mk |
|
Developmental Biology |
|||
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CD15/SSEA1 (MC480) Mouse mAb (Alexa Fluor? 488 Conjugate) |
IF-IC, F |
M |
|
|
ETV5 (E5G9V) Rabbit mAb |
WB, IP |
H, M |
|
|
Human FGF-9 Recombinant Protein |
- |
- |
|
|
Mouse FGF-9 Recombinant Protein |
- |
- |
|
|
HIF-1α (D1S7W) XP? Rabbit mAb (Biotinylated) |
WB |
H, M, Mk |
|
|
Notch2 (D76A6) XP? Rabbit mAb (Alexa Fluor? 488 Conjugate) |
IF-IC, F |
H, M, R |
|
|
POU2F3 (E5N2D) XP? Rabbit mAb |
WB, IHC-Bond, IHC-P |
H |
|
|
RUNX3/AML2 (E8D5W) XP? Rabbit mAb |
WB, IP, IHC-P |
H |
|
|
Human TGF-α Recombinant Protein |
- |
- |
|
|
YAP/TAZ (D24E4) Rabbit mAb (Alexa Fluor? 647 Conjugate) |
F |
H, M, Mk |
|
|
Glucose / Energy Metabolism |
|||
| 66933S | GPAT4 Antibody | WB | H |
|
Immunology and Inflammation |
|||
| 81123S | ASC/TMS1 (D2W8U) Rabbit mAb (Alexa Fluor? 555 Conjugate) | F | M |
| 29956S | ASC/TMS1 (D2W8U) Rabbit mAb (Alexa Fluor? 594 Conjugate) | F | M |
| 90776S | Bcl-3 (E2M6N) Rabbit mAb | WB, F | H |
| 16611S | Bcl-3 (E4D4K) Rabbit mAb | WB, IP, IHC-P | H, M |
| 64137S | Phospho-Btk (Tyr551) (E5Y6N) Rabbit mAb (Alexa Fluor? 647 Conjugate) | F | H |
| 16803S | Phospho-Btk (Tyr551) (E5Y6N) Rabbit mAb (PE Conjugate) | F | H |
| 88083S | CD3ζ Antibody | WB | H, M |
| 23578S | CD27 Antibody | WB | M |
| 26233S | CD34 (E2J1K) Rabbit mAb | WB, IF-F, IF-IC | M |
| 46894S | CD37 (E4K2M) Rabbit mAb | WB, IP, F | H |
| 55084S | CD74 (D5N3I) XP? Rabbit mAb (PE Conjugate) | F | H |
| 89660S | Phospho-CD79A (Tyr210) (E8E9Z) Rabbit mAb | WB, F | H |
| 57950S | CLEC12A/CLL-1 (E5T5V) Rabbit mAb | WB, IP, F | H |
|
CTLA-4 (E2V1Z) Rabbit mAb |
WB, IP, IHC-Bond, IHC-P |
H, M |
|
|
CTLA-4 (E2V1Z) Rabbit mAb (BSA and Azide Free) |
WB, IHC |
H, M |
|
| 87223S | DPEP-1/MDP (E4O6J) XP? Rabbit mAb | WB, IHC-P, IF-IC | H |
| 76290S | DPEP-1/MDP (E5C2V) Rabbit mAb | WB, IF-IC | H |
| 78401S | FcRγ (E6Y1A) Rabbit mAb | WB, IP, IHC-Bond, IHC-P, IF-F, IF-IC | H, M |
| 20085S | FcRn (E4D5I) Rabbit mAb | WB, IHC-P | M, R |
| 45850S | Fibrinogen gamma chain (E1U3Z) XP? Rabbit mAb | WB, IHC-Bond, IHC-P | H |
| 89572S | Galectin-3/LGALS3 (E7B6R) Rabbit mAb | WB, IP, IHC-P, IF-F, IF-IC | H, M, R |
| 99695S | Granzyme H (E3H7W) Rabbit mAb | WB, F | H |
| 61606S | HPK1 (E1C3L) Rabbit mAb (Biotinylated) | WB | H |
| 18526S | IL-2Rγ (E2Z5W) Rabbit mAb | WB, IP, F | M |
| 57529S | Human IL-11 Recombinant Protein | - | - |
| 76561S | Mouse IL-11 Recombinant Protein | - | - |
| 68350S | Integrin α11 Antibody | WB, IP | H |
| 98344S | IRF-8 (E8X4K) Rabbit mAb | WB, IP, IF-F, IF-IC, F, ChIP | H, M, R |
| 51817S | ITK (E4X7M) Rabbit mAb (Biotinylated) | WB | H |
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LAMP1 (E5N9Z) Rabbit mAb (Alexa Fluor? 488 Conjugate) |
IF-F, IF-IC |
M |
|
| 73294S | LAMP1 (E5N9Z) Rabbit mAb (Alexa Fluor? 594 Conjugate) | IF-F, IF-IC | M |
| 98215S | MSR1 (E7P6W) Rabbit mAb | IHC-P | M |
| 10054S | NEK7 Antibody | WB | H, M |
| 96874S | Phospho-NF-κB p65 (Ser529) Antibody | WB | H |
| 84223T | Human Reactive M1 vs M2 Macrophage IHC Antibody Sampler Kit | - | - |
| 97624T | Mouse Reactive M1 vs M2 Macrophage IHC Antibody Sampler Kit | - | - |
| PathScan? Phospho-Stat1 (Tyr701) Sandwich ELISA Kit | ELISA | H, M | |
| 73452S | Phospho-Stat3 (Tyr705) (D3A7) XP? Rabbit mAb (Alexa Fluor? 555 Conjugate) | F | H, M, R, Mk, (Hm, B, Pg, Hr) |
| 61958S | Phospho-Stat3 (Tyr705) (D3A7) XP? Rabbit mAb (Alexa Fluor? 594 Conjugate) | F | H, M, R, Mk, (Hm, B, Pg, Hr) |
| 72337S | TNF-R2 (E8D7P) Rabbit mAb | WB, IP, F | H |
| 38519S | Toll-like Receptor 4 (E5D8T) Rabbit mAb | WB | H |
| 58125S | Tox (E5J8A) Rabbit mAb | IF-IC, F | H |
| 74698S | SARS-CoV-2 Envelope Protein Antibody | WB | Vir |
| 37393C | PathScan? SARS-CoV-2 Nucleocapsid Protein Sandwich ELISA Kit | ELISA | Vir |
| 34340S | SARS-CoV-2 ORF3a Antibody | WB, IP | Vir |
| MEK5 (E4C4B) Rabbit mAb | WB, IP | H, M, R | |
| AGK Antibody | WB | H | |
| 24972S | AIFM2/FSP1 Antibody | WB | H |
| 31219S | COX2/MT-CO2 Antibody | WB, IP | H, Mk |
| 26381S | DHODH (E9X8R) Rabbit mAb | WB | H, M, R |
| 17412S | MT-ATP8 Antibody | WB, IP | H |
| 45535S | Perilipin-2 Antibody | WB, IP | H |
| 65675S | TOM70 Antibody | WB | H, M, R |
| 53370S | Xanthine Dehydrogenase/Oxidase Antibody | WB | H |
|
PTMScan? HS Acetyl-Lysine Motif (Ac-K) Kit |
- |
- |
|
|
PathScan? β-Amyloid (1-40) Sandwich ELISA Kit |
ELISA |
H |
|
|
ApoE (E7X2A) Rabbit mAb |
WB, IP, IHC-P, IF-F, IF-IC |
M |
|
| 80718S | DNAJC7 Antibody | WB | H, M, R |
| 90963S | Neurexin-3 Antibody | WB | H, M, R |
|
α-Synuclein (E4U2F) XP? Rabbit mAb |
WB, IP, IHC-P, IF-F, IF-IC |
H, M, R |
|
|
TREM2-dependent mTOR Metabolic Fitness Antibody Sampler Kit |
- |
- |
|
| 96453S | Phospho-Axl (Tyr779) Antibody | WB, IP | H |
| 76799S | HER2/ErbB2 (CB11) Mouse mAb | IHC-Bond, IHC-P | H |
|
Translational Control |
|||
| 41025S | ADAR1 (E6X9R) XP? Rabbit mAb (Alexa Fluor? 488 Conjugate) | IF-IC, F | H, Mk |
| 31358S |
DIMT1 Antibody |
WB |
H, M, R, Mk |
|
Ubiquitin and Ubiquitin-like proteins |
|||
| 17579S | PSMB10/MECL-1 (E6R7O) Rabbit mAb | WB | H, M |
|
Related Products |
|||
| 20533S |
10% SDS Solution |
C&R |
- |
| 5708S | Anti-biotin (D5A7) Rabbit mAb (Alexa Fluor? 488 Conjugate) | F | All |
|
Glycine Solution (10X) |
ChIP, C&R |
- |
|
| 20664S | His-Tag (D3I1O) XP? Rabbit mAb (Alexa Fluor? 555 Conjugate) | IF-IC, F | All |
| 81940S | His-Tag (D3I1O) XP? Rabbit mAb (Alexa Fluor? 594 Conjugate) | IF-IC, F | All |
| 67476S | V5-Tag (D3H8Q) Rabbit mAb (Sepharose? Bead Conjugate) | IP | All |
| 83862S | V5-Tag (E9H8O) Mouse mAb (Sepharose? Bead Conjugate) | IP | All |
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2. Brunet, J.F. et al. (1987) Nature 328, 267-70.
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5. Collins, A.V. et al. (2002) Immunity 17, 201-10.
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