Mouse IL-1 beta PicoKine ELISA Kit
- 【品牌】: 博士德
- 【產(chǎn)品貨號(hào)】: EK0394
- 【價(jià)格】: 1980 元
- 【規(guī)格】: 96T
- 【貨期】:
| 產(chǎn)品說(shuō)明 | |
| 【品牌】: | 博士德 |
| 【產(chǎn)品貨號(hào)】: | EK0394 |
| 【價(jià)格】: | 1980 元 |
| 【規(guī)格】: | 96T |
| 【貨期】: | |
| 【儲(chǔ)存溫度】: | -20 |
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Interleukin-1beta(IL-1beta) is a potent stimulator of bone resorption whose gene is mapped to 2q14, and has been implicated in the pathogenesis of high bone turnover and osteoporosis. IL-1beta, a prominent microglia-derived cytokine, caused oligodendrocyte death in coculture with astrocytes and microglia, but not in pure culture of oligodendrocytes alone1. It also can cause nuclear export of a specific NCOR corepressor complex, resulting in derepression of a specific subset of nuclear factor-kappa-B(NFKB)-regulated genes2. Furthermore, Microenvironmental IL-1beta and, to a lesser extent, IL-1alpha are required for in vivo angiogenesis and invasiveness of different tumor cells3. Additional, the cooperation of IL-1beta and PDGFB induces contractile-to-synthetic phenotype modulation of human aortic smooth muscle cells in culture4. Moreover, the association with disease may be explained by the biologic properties of IL-1beta, which is an important proinflammatory cytokine and a powerful inhibitor of gastric acid secretion.
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